Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646366 | 0.95 | CSNK1E (0.44) | ENPP2NOS1NOS2ALDH1A1CYP3A4 | |
| SCHEMBL1945278 | 0.92 | ENPP2 (0.44) | ENPP2NOS1NOS2ALDH1A1CYP3A4 | |
| SCHEMBL6055343 | 0.86 | ALDH1A1 (0.42) | ALDH1A1KDM4ECYP3A4NFKB1SMN1; SMN2 | |
| SCHEMBL13092691 | 0.85 | PNMT (0.40) | ENPP2NOS1NOS2ALDH1A1KLKB1 | |
| SCHEMBL27536091 | 0.84 | LMNA (0.53) | ENPP2NOS1NOS2ALDH1A1CYP3A4 | |
| SCHEMBL14642896 | 0.83 | LPL (0.42) | NOS1NOS2 | |
| SCHEMBL9646349 | 0.82 | S1PR2 (0.43) | NOS1NOS2ALDH1A1KDM4ENFKB1 | |
| SCHEMBL13593566 | 0.82 | PNMT (0.38) | ENPP2NOS1NOS2ALDH1A1KDM4E | |
| SCHEMBL3189343 | 0.81 | LPL (0.44) | ALDH1A1CYP3A4NFKB1SMN1; SMN2MAPK1 | |
| SCHEMBL28089967 | 0.81 | ENPP2 (0.39) | ENPP2NOS1NOS2ALDH1A1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778931-A | ENZYME INHIBITORS | USV PHARMACEUTICAL CORPORATION (US) | 1988-10-18 | — | — | US | disclosed |
| EP-0181568-A2 | Anti-inflammatory/anti-allergic compounds | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1986-05-21 | — | — | EP | disclosed |