Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 13/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646165 | 0.92 | CTSK (0.45) | CTSSCTSKRENAAK1 | |
| SCHEMBL9646344 | 0.89 | CTSS (0.43) | CTSSCTSKRENAAK1 | |
| SCHEMBL7334369 | 0.86 | REN (0.32) | CTSSCTSKREN | |
| SCHEMBL9646634 | 0.85 | CTSK (0.40) | CTSSCTSKRENAAK1 | |
| SCHEMBL7274679 | 0.85 | REN (0.55) | REN | |
| SCHEMBL9646563 | 0.82 | CTSK (0.40) | CTSSCTSKRENAAK1 | |
| SCHEMBL7274926 | 0.81 | CTSK (0.47) | CTSSCTSKREN | |
| SCHEMBL7277428 | 0.79 | CTSK (0.37) | CTSKRENSMN1; SMN2 | |
| SCHEMBL9646949 | 0.78 | CTSK (0.52) | CTSSCTSKRENAAK1 | |
| Bromide SCHEMBL10716005 | 0.78 | CTSK (0.36) | CTSKRENSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | claimed |
| US-5147867-A | Bactericides, (carba)penicillins | MERCK & CO., INC. (US) | 1992-09-15 | — | — | US | disclosed |
| US-5145990-A | Dehydropeptidase, carbapenicillin potentiation | MERCK & CO., INC. (US) | 1992-09-08 | — | — | US | disclosed |
| US-4962097-A | IN COMBINATION WITH A CARBAPENEM OR PENEM ANTIBIOTIC | MERCK & CO., INC. (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0366469-A2 | Phosphorus containing enzyme inhibitors | MERCK & CO. INC. (US) | 1990-05-02 | — | — | EP | disclosed |
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0209848-A2 | Enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | disclosed |