Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL153943 | 0.92 | TSHR (0.67) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| Hydrochloric Acid SCHEMBL2801770 | 0.88 | TSHR (0.62) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| Hydrochloric Acid SCHEMBL6241253 | 0.88 | TSHR (0.62) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| Bromide SCHEMBL7630752 | 0.88 | TSHR (0.62) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| SCHEMBL7338618 | 0.81 | TSHR (0.56) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| SCHEMBL5147226 | 0.81 | KIF11 (0.64) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| SCHEMBL28208083 | 0.79 | — | — | |
| SCHEMBL16141203 | 0.79 | — | — | |
| SCHEMBL22126282 | 0.79 | TSHR (0.53) | TSHRAPPALDH1A1RECQLHSD17B10 | |
| SCHEMBL44533 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110718-A | Improved retention stability of dispersion solution; less perspirability | KONICA CORPORATION (JP) | 1992-05-05 | — | — | US | disclosed |
| EP-0349327-A2 | Silver halide photographic light sensitive material | KONICA CORPORATION (JP) | 1990-01-03 | — | — | EP | disclosed |