Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.50 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.48 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.48 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.48 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.39 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.35 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.35 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | APP | P05067 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6241253 | 1.00 | TSHR (0.62) | TSHRAPPALDH1A1MAPTRECQL | |
| SCHEMBL153943 | 0.96 | TSHR (0.67) | TSHRAPPALDH1A1MAPTRECQL | |
| Bromide SCHEMBL7630752 | 0.92 | TSHR (0.62) | TSHRAPPALDH1A1MAPTRECQL | |
| Hydrochloric Acid SCHEMBL9647124 | 0.88 | TSHR (0.59) | TSHRAPPALDH1A1MAPTRECQL | |
| Hydrochloric Acid SCHEMBL2866389 | 0.87 | MAPT (0.50) | TSHRAPPALDH1A1MAPTRECQL | |
| SCHEMBL7338618 | 0.85 | TSHR (0.56) | TSHRAPPALDH1A1MAPTRECQL | |
| SCHEMBL5147226 | 0.85 | KIF11 (0.64) | TSHRAPPALDH1A1MAPTRECQL | |
| Hydrochloric Acid SCHEMBL8724196 | 0.84 | ALDH1A1 (0.73) | TSHRAPPALDH1A1MAPTRECQL | |
| Hydrochloric Acid SCHEMBL6010014 | 0.84 | TSHR (0.48) | TSHRAPPALDH1A1MAPTRECQL | |
| Hydrochloric Acid SCHEMBL10343601 | 0.84 | ALDH1A1 (0.48) | TSHRAPPALDH1A1MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834697-B2 | Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2023-12-05 | — | — | US | disclosed |
| CN-116940828-A | Method for determining total aldehydes in one or more of crude 2, 5-furandicarboxylic acid (FDCA), crude terephthalic acid (TPA), and esters thereof | 阿彻丹尼尔斯米德兰德公司 | 2023-10-24 | — | — | CN | disclosed |
| US-20200199644-A1 | ELECTROCHEMICAL RECOGNITION AND QUANTIFICATION OF CYTOCHROME C OXIDASE EXPRESSION IN BACTERIA | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2020-06-25 | — | — | US | disclosed |
| US-8530191-B2 | Method for preventing formation of trisulfide derivatives of polypeptides | NOVO NORDISK A/S (DK) | 2013-09-10 | — | — | US | disclosed |
| US-20100160236-A1 | Method for Preventing Formation of Trisulfide Derivatives of Polypeptides | NOVO NORDISK HEALTHCARE A/G (CH) | 2010-06-24 | — | — | US | disclosed |
| EP-1833841-B1 | METHOD FOR PREVENTING FORMATION OF TRISULFIDE DERIVATIVES OF POLYPEPTIDES | NOVO NORDISK HEALTHCARE AG (CH) | 2010-04-07 | — | — | EP | disclosed |
| US-20090131311-A1 | Method for Preventing Formation of Trisulfide Derivatives of Polypeptides | NOVO NORDISK HEALTHCARE AG | 2009-05-21 | — | — | US | disclosed |
| US-4009154-A | Process for preparing aromatic polyamides with sodium carbonate hydrate as acid acceptor | TEIJIN LIMITED (JA) | 1977-02-22 | — | — | US | disclosed |