Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4805089 | 0.77 | TDP1 (0.34) | ACHETDP1 | |
| SCHEMBL4806936 | 0.76 | ACHE (0.35) | ACHE | |
| SCHEMBL4804521 | 0.70 | LMNA (0.35) | TDP1 | |
| SCHEMBL4809916 | 0.69 | MAPK1 (0.38) | TDP1 | |
| SCHEMBL4804592 | 0.68 | KDM4E (0.32) | — | |
| SCHEMBL9650425 | 0.68 | CHRNB4 (0.35) | — | |
| SCHEMBL2545284 | 0.68 | — | — | |
| SCHEMBL16817006 | 0.67 | TDP1 (0.36) | ACHETDP1 | |
| SCHEMBL5180094 | 0.64 | ALDH1A1 (0.32) | — | |
| SCHEMBL4008031 | 0.63 | ALDH1A1 (0.39) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |