Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867317 | 0.90 | CTSS (0.46) | CTSKCTSSALDH1A1TSHRATM | |
| SCHEMBL8867310 | 0.90 | CTSS (0.46) | CTSKCTSSALDH1A1TSHRATM | |
| SCHEMBL23611112 | 0.83 | CTSK (0.49) | CTSKCTSSATMHDAC4HDAC1 | |
| SCHEMBL23611110 | 0.83 | CTSK (0.49) | CTSKCTSSATMHDAC4HDAC1 | |
| SCHEMBL11876457 | 0.81 | CTSS (0.47) | CTSKCTSSRORCALDH1A1HDAC4 | |
| SCHEMBL11290382 | 0.81 | ADRB3 (0.42) | CTSKCTSSHDAC1 | |
| SCHEMBL11880230 | 0.81 | L3MBTL1 (0.48) | CTSKCTSSHDAC4HDAC1BACE1 | |
| SCHEMBL11875007 | 0.80 | CTSK (0.49) | CTSKCTSSATMHDAC4HDAC1 | |
| SCHEMBL11573224 | 0.80 | CTSK (0.46) | CTSKCTSSHDAC4HDAC1BACE1 | |
| SCHEMBL11573817 | 0.78 | CTSS (0.47) | CTSKCTSSALDH1A1HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266896-B1 | 7-( (META-SUBSTITUTED) PHENYLGLYCINE) 1-CARBA-1-DETHIACEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1992-08-05 | — | — | EP | disclosed |
| EP-0266896-A1 | 7-( (Meta-substituted) phenylglycine) 1-carba-1-dethiacephalosporins | ELI LILLY AND COMPANY (US) | 1988-05-11 | — | — | EP | disclosed |