Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL3864476 | 0.93 | MEN1 (0.59) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Tetrabuthylammonium SCHEMBL10876238 | 0.92 | DNM1 (0.57) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Tetrabuthylammonium SCHEMBL9136922 | 0.92 | MEN1 (0.57) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| SCHEMBL383279 | 0.90 | DNM1 (0.51) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Tetrabuthylammonium SCHEMBL7114513 | 0.90 | DNM1 (0.59) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Hexane SCHEMBL9016836 | 0.90 | DNM1 (0.59) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8527490 | 0.90 | MEN1 (0.58) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11126527 | 0.88 | MEN1 (0.66) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| SCHEMBL12558342 | 0.88 | DNM1 (0.56) | MEN1KMT2ATP53MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11129711 | 0.86 | MEN1 (0.69) | MEN1KMT2ATP53MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127216-B1 | PROCESS FOR THE PREPARATION OF 21-HYDROXY-20-KETO-DELTA16-STEROIDS AND INTERMEDIATE COMPOUNDS FORMED IN THIS PROCESS | ROUSSEL-UCLAF (FR) | 1992-01-02 | — | — | EP | disclosed |
| EP-0127216-A1 | Process for the preparation of 21-hydroxy-20-keto-delta16-steroids and intermediate compounds formed in this process | ROUSSEL-UCLAF (FR) | 1984-12-05 | — | — | EP | disclosed |