Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656646 | 0.65 | GABRR1 (0.41) | MCL1CYP1A2CYP3A4ADRA2CHTR2A | |
| SCHEMBL9655794 | 0.63 | MCL1 (0.48) | MCL1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9655802 | 0.63 | MCL1 (0.48) | MCL1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL27852172 | 0.62 | MCL1 (0.49) | MCL1KMT2ATERTNPC1RAB9A | |
| SCHEMBL9887744 | 0.61 | KMT2A (0.55) | MCL1KMT2ATERTMEN1DAO | |
| Fumaric Acid SCHEMBL9656647 | 0.61 | GABRR1 (0.43) | MCL1CYP1A2CYP3A4ADRA2CHTR2A | |
| Fumaric Acid SCHEMBL7323811 | 0.61 | HTR3E (0.44) | MCL1HTR3A | |
| SCHEMBL12260539 | 0.60 | KMT2A (0.53) | MCL1KMT2ATERTMEN1DAO | |
| SCHEMBL10550209 | 0.59 | SLC6A2 (0.38) | KMT2AMAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL20746874 | 0.59 | KMT2A (0.52) | MCL1KMT2ATERTMEN1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084474-A | Antagonist of 5-hydroxytryptamine receptors on nerves and useful for treatment of psychotic disorders, anxiety, and nausea and vomiting, compounds of imidazole | GLAXO GROUP LIMITED (GB) | 1992-01-28 | — | — | US | disclosed |