Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654495 | 0.87 | HDAC1 (0.52) | HDAC4HDAC1HDAC8PKMALDH1A1 | |
| SCHEMBL9656899 | 0.86 | TBXAS1 (0.51) | ALDH1A1MAPT | |
| SCHEMBL9656327 | 0.86 | PTGDR2 (0.48) | PGRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9656295 | 0.84 | TSHR (0.54) | PGRHDAC1HDAC8 | |
| SCHEMBL9657802 | 0.84 | HDAC1 (0.53) | HDAC4HDAC1HDAC8PKMALDH1A1 | |
| SCHEMBL9656313 | 0.83 | TBXAS1 (0.53) | MAPT | |
| SCHEMBL9656043 | 0.82 | TBXAS1 (0.51) | ALDH1A1 | |
| SCHEMBL9656883 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9654550 | 0.80 | IDO1 (0.49) | HDAC1HDAC8ALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL9657786 | 0.79 | CES1 (0.51) | ALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287270-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-12-30 | — | — | EP | claimed |
| EP-0287270-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-19 | — | — | EP | claimed |
| EP-0287270-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-4902698-A | Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub.2 | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-20 | — | — | US | disclosed |
| EP-0287270-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |