Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | FABP1 | P07148 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654495 | 0.96 | HDAC1 (0.52) | HDAC1FABP1ALDH1A1TBXA2RHDAC8 | |
| SCHEMBL9656313 | 0.89 | TBXAS1 (0.53) | TBXA2RMEN1KMT2ATBXAS1 | |
| SCHEMBL9656899 | 0.85 | TBXAS1 (0.51) | ALDH1A1TBXA2RMEN1KMT2ATBXAS1 | |
| SCHEMBL9654550 | 0.85 | IDO1 (0.49) | HDAC1FABP1ALDH1A1HDAC8MEN1 | |
| SCHEMBL9656883 | 0.85 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL9656277 | 0.84 | KMT2A (0.48) | HDAC1ALDH1A1HDAC8MEN1KMT2A | |
| SCHEMBL9656208 | 0.84 | PGR (0.52) | HDAC1ALDH1A1HDAC8HDAC4TDP1 | |
| SCHEMBL10471236 | 0.84 | FABP1 (0.47) | HDAC1FABP1ALDH1A1TBXA2RHDAC8 | |
| SCHEMBL9656939 | 0.82 | HDAC1 (0.52) | HDAC1ALDH1A1HDAC8HDAC4POLB | |
| SCHEMBL9656295 | 0.81 | TSHR (0.54) | HDAC1HDAC8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287270-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-4902698-A | Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub.2 | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-20 | — | — | US | disclosed |
| EP-0287270-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |