Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9654495 | 0.85 | HDAC1 (0.52) | HDAC1HDAC8KMT2AMEN1 | |
| SCHEMBL9656208 | 0.84 | PGR (0.52) | PGRHDAC1HDAC8 | |
| SCHEMBL9517143 | 0.84 | TSHR (0.61) | TSHRNR3C1PGRARESR2 | |
| SCHEMBL9657802 | 0.81 | HDAC1 (0.53) | HDAC1HDAC8KMT2AMEN1 | |
| SCHEMBL9656327 | 0.79 | PTGDR2 (0.48) | PGRHDAC1HDAC8KMT2AMEN1 | |
| SCHEMBL27630137 | 0.79 | MEN1 (0.60) | TSHRNR3C1PGRARESR2 | |
| SCHEMBL9656899 | 0.77 | TBXAS1 (0.51) | KMT2AMEN1 | |
| SCHEMBL9654550 | 0.77 | IDO1 (0.49) | ARHDAC1HDAC8KMT2AMEN1 | |
| SCHEMBL9656883 | 0.77 | ALDH1A1 (0.60) | KMT2AGAAMEN1CA2CA1 | |
| SCHEMBL10471236 | 0.76 | FABP1 (0.47) | HDAC1HDAC8KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287270-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-4902698-A | Benzenesulphonamidopyridyl compounds which are useful as thromboxane A.sub.2 | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-20 | — | — | US | disclosed |
| EP-0287270-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |