Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657742 | 0.83 | ERN1 (0.44) | RNASEH1TRPA1PTGS1CACNA1CALDH1A1 | |
| SCHEMBL9654846 | 0.80 | CSNK2A2 (0.43) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9657787 | 0.78 | HPGD (0.44) | MAPTALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL9657182 | 0.78 | TSHR (0.44) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9656717 | 0.78 | PPM1A (0.40) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9657859 | 0.77 | LMNA (0.50) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL4858393 | 0.77 | TRPA1 (0.50) | MAPTMAPK1TDP1L3MBTL1RNASEH1 | |
| SCHEMBL10149066 | 0.77 | ALDH1A1 (0.54) | MAPTMAPK1TDP1L3MBTL1RNASEH1 | |
| SCHEMBL29700360 | 0.77 | LMNA (0.50) | MAPTMAPK1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9627506 | 0.76 | TYR (0.37) | MAPTMAPK1TDP1L3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |