Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658026 | 0.89 | TTR (0.47) | KDM4EHSD17B10HPGDTTRCYP1A2 | |
| SCHEMBL9660313 | 0.87 | KDM4E (0.47) | KDM4EHSD17B10HPGDCYP1A2CYP2C9 | |
| SCHEMBL9659562 | 0.86 | ALDH1A1 (0.47) | KDM4EHSD17B10HPGDTTRCYP1A2 | |
| SCHEMBL9659406 | 0.86 | PKM (0.48) | TTRRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL30227041 | 0.85 | KDM4E (0.39) | KDM4EHSD17B10HPGDTTRCYP1A2 | |
| SCHEMBL9659258 | 0.83 | HTR1A (0.51) | KDM4EHPGDCYP1A2CYP2C9IDO1 | |
| SCHEMBL19612272 | 0.82 | ALDH1A1 (0.48) | KDM4EHPGDTTRIDO1HTT | |
| SCHEMBL9657784 | 0.81 | KMT2A (0.42) | KDM4EHPGDTTRHTTKMT2A | |
| SCHEMBL9658296 | 0.81 | HTT (0.40) | KDM4ETTRCYP1A2CYP2C9HTT | |
| SCHEMBL10643489 | 0.81 | HTT (0.46) | KDM4EHSD17B10HPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |