Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658738 | 0.85 | NPC1 (0.36) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9658741 | 0.85 | NPC1 (0.36) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9690044 | 0.82 | KMT2A (0.43) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9690040 | 0.82 | KMT2A (0.43) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9660705 | 0.80 | ALDH1A1 (0.35) | LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9660909 | 0.80 | KIF11 (0.39) | RAB9AKMT2AMAPTKDM4EMEN1 | |
| SCHEMBL9660700 | 0.80 | ALDH1A1 (0.35) | LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9661588 | 0.78 | NPC1 (0.44) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9661581 | 0.78 | NPC1 (0.44) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL9690654 | 0.76 | MAPT (0.55) | NPC1RAB9AKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520274-A2 | 2-(-4-substituted-phenylhydrazino)-2-thiazoline and 2-(-4-substituted phenylazo)-2-thiazoline, their preparation and their use against ectoparasites | BAYER AG (DE) | 1992-12-30 | — | — | EP | disclosed |