Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12188944 | 0.82 | ALDH1A1 (0.64) | KCNH2HRH3HSD11B1TP53AKR1C3 | |
| SCHEMBL4516709 | 0.80 | PKM (0.57) | KCNH2HRH3HSD11B1ALDH1A1RAB9A | |
| SCHEMBL3235054 | 0.80 | PKM (0.57) | KCNH2HRH3HSD11B1ALDH1A1RAB9A | |
| SCHEMBL3235046 | 0.80 | PKM (0.57) | KCNH2HRH3HSD11B1ALDH1A1RAB9A | |
| SCHEMBL12730547 | 0.78 | KMT2A (0.64) | ALDH1A1MEN1KMT2A | |
| SCHEMBL846953 | 0.77 | AKR1C3 (0.49) | KCNH2HRH3HSD11B1MAPTAKR1C3 | |
| SCHEMBL19563449 | 0.77 | TDO2 (0.52) | KCNH2HRH3HSD11B1MAPTAKR1C3 | |
| SCHEMBL5254329 | 0.77 | LMNA (0.62) | TP53MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5915284 | 0.77 | LMNA (0.62) | TP53MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL21772288 | 0.77 | AKR1C3 (0.54) | KCNH2HRH3HSD11B1AKR1C3TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490765-A2 | 1-Arylsulfonyl-2-pyrrolidone-derivatives, process for their preparation, new in termediates, use for medicaments and drugs containing them | ROUSSEL-UCLAF (FR) | 1992-06-17 | — | — | EP | disclosed |