Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | HTR1A | P08908 | 3/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.70 |
| ▸ | DRD3 | P35462 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.70 |
| ▸ | DRD1 | P21728 | 1/20 | 0.70 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.70 |
| ▸ | CASR | P41180 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9661904 | 0.86 | LMNA (0.59) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL15131187 | 0.84 | LMNA (0.70) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL9661837 | 0.84 | HTR1A (0.80) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| SCHEMBL9660642 | 0.83 | HTR1A (0.86) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Fendiline SCHEMBL14415809 | 0.83 | OPRM1 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Fendiline SCHEMBL63814 | 0.83 | OPRM1 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Fendiline SCHEMBL14415808 | 0.83 | OPRM1 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Fendiline SCHEMBL5053865 | 0.83 | OPRM1 (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9661761 | 0.83 | KMT2A (0.81) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 | |
| Fendiline SCHEMBL15571059 | 0.81 | KMT2A (1.00) | SLC6A2SLC6A4SLC6A3KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253327-B1 | DIPHENYLPROPYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1992-05-06 | — | — | EP | claimed |
| EP-0253327-A2 | Diphenylpropylamine derivatives, their preparation and their pharmaceutical use | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1988-01-20 | — | — | EP | claimed |