Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156544 | 0.83 | LTA4H (0.61) | LTA4HPTGS1PTGS2HRH3KCNH2 | |
| SCHEMBL16181823 | 0.82 | HRH3 (0.63) | LTA4HHRH3KCNH2KDM4ECYP3A4 | |
| SCHEMBL9660648 | 0.81 | LTA4H (0.65) | LTA4HPTGS1PTGS2HRH3KCNH2 | |
| SCHEMBL56495 | 0.80 | LTA4H (0.90) | LTA4HPTGS1PTGS2HRH3KCNH2 | |
| SCHEMBL1547055 | 0.80 | DRD4 (0.72) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL1546881 | 0.80 | DRD4 (0.72) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL23724061 | 0.79 | LTA4H (0.87) | LTA4HPTGS1PTGS2HRH3KCNH2 | |
| SCHEMBL3937460 | 0.79 | LTA4H (0.87) | LTA4HPTGS1PTGS2HRH3KCNH2 | |
| Hydrochloric Acid SCHEMBL15254264 | 0.79 | LTA4H (0.87) | LTA4HPTGS1PTGS2HRH3KCNH2 | |
| SCHEMBL9660685 | 0.78 | DRD2 (0.50) | DRD2DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307121-B1 | SULPHONAMIDE ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1992-03-18 | — | — | EP | disclosed |
| EP-0307121-A1 | Sulphonamide antiarrhythmic agents | Pfizer Limited (GB) | 1989-03-15 | — | — | EP | disclosed |