Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24460758 | 0.84 | ALDH1A1 (0.59) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL1546881 | 0.83 | DRD4 (0.72) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL1547055 | 0.83 | DRD4 (0.72) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL24460772 | 0.79 | ALDH1A1 (0.53) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL9661978 | 0.79 | HRH3 (0.68) | SIGMAR1 | |
| SCHEMBL9234885 | 0.78 | HRH3 (0.47) | SIGMAR1 | |
| SCHEMBL9660692 | 0.78 | LTA4H (0.61) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL5651768 | 0.78 | SIGMAR1 (0.64) | SIGMAR1 | |
| SCHEMBL1877934 | 0.78 | HRH3 (0.68) | SIGMAR1 | |
| SCHEMBL14205029 | 0.77 | SLC6A1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307121-B1 | SULPHONAMIDE ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1992-03-18 | — | — | EP | disclosed |
| EP-0307121-A1 | Sulphonamide antiarrhythmic agents | Pfizer Limited (GB) | 1989-03-15 | — | — | EP | disclosed |