SCHEMBL9663142

SCHEMBL9663142

Nc1nc(Cl)c2ncn(OCc3ccccc3)c2n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 5/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC6 Q9UBN7 6/20 0.46
HDAC4 P56524 1/20 0.46
HSP90AA1 P07900 6/20 0.43
HSP90AB1 P08238 6/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
HIF1A Q16665 1/20 0.43
PHLPP2 Q6ZVD8 1/20 0.43
CDK1 P06493 2/20 0.41
ADORA2A P29274 2/20 0.40
ADORA1 P30542 2/20 0.40
HRH4 Q9H3N8 1/20 0.40
CCNB1 P14635 1/20 0.39
MGMT P16455 1/20 0.39
CCNA2 P20248 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9417236 0.82 CDK1 (0.42) HSP90AA1HSP90AB1ALDH1A1CYP1A2CYP3A4
SCHEMBL9417133 0.81 ACHE (0.36) HDAC1HDAC2HDAC6HDAC4ALDH1A1
SCHEMBL9417239 0.80 DAPK1 (0.49) HDAC6CYP1A2ADORA2A
SCHEMBL6272417 0.78 ALDH1A1 (0.66) HDAC1HDAC2HDAC6HDAC4HSP90AA1
SCHEMBL7702157 0.77 PNP (0.64) PNP
SCHEMBL10996722 0.77 HDAC1 (0.47) HDAC1HDAC2HDAC6HDAC4HSP90AA1
Hydrochloric Acid SCHEMBL17186409 0.76 PNP (0.62) PNP
SCHEMBL14477480 0.76 HDAC6 (0.51) HDAC1HDAC2HDAC6HDAC4HSP90AA1
SCHEMBL9187025 0.76 HSP90AB1 (0.42) HDAC1HDAC6HDAC4HSP90AA1HSP90AB1
SCHEMBL28016416 0.76 HDAC6 (0.42) HDAC6ALDH1A1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5159076-A Purine intermediates BEECHAM GROUP P.L.C. (GB) 1992-10-27 US disclosed