Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK1 | P53355 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125187 | 0.83 | ADORA2A (0.59) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL9663142 | 0.80 | HDAC1 (0.46) | ADORA2AHDAC6CYP1A2 | |
| SCHEMBL9417173 | 0.77 | GRM5 (0.42) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL30984022 | 0.76 | ADORA2A (0.70) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL2980291 | 0.76 | ADORA2A (0.70) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL5459069 | 0.75 | DAPK1 (0.67) | DAPK1ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL28003435 | 0.74 | FDPS (0.43) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9417133 | 0.74 | ACHE (0.36) | DAPK1ADORA2AHDAC6CYP1A2HPGD | |
| SCHEMBL9417129 | 0.73 | DAPK1 (0.33) | DAPK1HDAC6FGFR1FGFR4 | |
| SCHEMBL5440115 | 0.72 | LTA4H (0.50) | DAPK1HDAC6MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319228-B1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| US-5247085-A | Phosphonate containing purine compounds | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | disclosed |
| US-5166198-A | Herpes virus infections | BEECHAM P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0404296-A1 | Phosphono derivatives of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1990-12-27 | — | — | EP | disclosed |
| EP-0319228-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1989-06-07 | — | — | EP | disclosed |