Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10579576 | 0.84 | MAOA (0.39) | HTR5AIDO1CYP11B2CYP19A1CYP1A2 | |
| SCHEMBL3279244 | 0.80 | IDO1 (0.41) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9664804 | 0.79 | CYP11B1 (0.40) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9524640 | 0.78 | SLC9A1 (0.38) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9195882 | 0.77 | HTR5A (0.44) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9196161 | 0.77 | IDO1 (0.43) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL3279905 | 0.76 | CTNNB1 (0.46) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL7453705 | 0.75 | HTR5A (0.40) | HTR5AIDO1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL7463718 | 0.74 | NPC1 (0.44) | HTR5AIDO1CYP11B1CYP11B2FGFR1 | |
| SCHEMBL9664994 | 0.74 | CYP19A1 (0.52) | CYP11B1CYP11B2CYP19A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |