Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 10/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9663726 | 0.80 | CYP11B1 (0.53) | CYP19A1TBXAS1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL18413510 | 0.73 | CNR2 (0.53) | CYP11B1CYP11B2CNR2 | |
| SCHEMBL9662907 | 0.72 | CCNT1 (0.46) | CYP2B6CYP19A1TBXAS1CYP11B1CYP11B2 | |
| SCHEMBL9524167 | 0.70 | S1PR1 (0.44) | CYP2B6CYP19A1TBXAS1CYP11B1CYP11B2 | |
| SCHEMBL9665018 | 0.70 | CYP19A1 (0.44) | CYP2B6CYP19A1TBXAS1CYP11B1CYP11B2 | |
| SCHEMBL9663766 | 0.69 | CYP11B1 (0.44) | CYP19A1TBXAS1CYP11B1CYP11B2CYP17A1 | |
| SCHEMBL9664756 | 0.65 | CYP19A1 (0.54) | CYP2B6CYP19A1TBXAS1CYP11B1CYP11B2 | |
| SCHEMBL570574 | 0.65 | CYP2B6 (1.00) | CYP2B6CYP19A1TBXAS1 | |
| SCHEMBL20076324 | 0.65 | CYP2B6 (1.00) | CYP2B6CYP19A1TBXAS1 | |
| SCHEMBL11047040 | 0.65 | CYP2B6 (1.00) | CYP2B6CYP19A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |