SCHEMBL9665341

SCHEMBL9665341

Clc1ccc(C2(Cn3cncn3)COC(CBr)O2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.46
CYP2C9 P11712 3/20 0.46
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 2/20 0.41
THRB P10828 1/20 0.41
HSP90AA1 P07900 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
KDM4E B2RXH2 2/20 0.37
POLB P06746 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 3/20 0.36
ALDH1A1 P00352 2/20 0.36
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.35
GAA P10253 1/20 0.35
HSD17B10 Q99714 1/20 0.35
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10517012 1.00 CYP3A4 (0.46) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL27545132 0.91 CYP3A4 (0.44) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL6151963 0.89 CYP3A4 (0.41) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL6151930 0.86 CYP3A4 (0.62) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL6151927 0.86 CYP3A4 (0.62) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL9567574 0.82 CYP3A4 (0.52) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL27545135 0.81 CYP3A4 (0.44) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL11212871 0.81 CYP3A4 (0.43) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL6152242 0.79 HMOX1 (0.42)
SCHEMBL6152239 0.79 HMOX1 (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0278105-B1 2,4,4-TRI- AND 2,2,4,4-TETRA-SUBSTITUTED-1,3-DIOXOLANE SCHERING CORP (US) 1992-05-06 EP disclosed
EP-0329711-A1 2,4,4-TRI- AND 2,2,4,4-TETRA SUBSTITUTED-1,3-DIOXOLANE COMPOUNDS SCHERING CORPORATION (US) 1989-08-30 EP disclosed
US-4788190-A 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds SCHERING CORPORATION (US) 1988-11-29 US disclosed
EP-0278105-A1 2,4,4-Tri- and 2,2,4,4-tetra-substituted-1,3-dioxolane SCHERING CORPORATION (US) 1988-08-17 EP disclosed
WO-1988005048-A1 2,4,4-TRI- AND 2,2,4,4-TETRA SUBSTITUTED-1,3-DIOXOLANE COMPOUNDS SCHERING CORPORATION (US) 1988-07-14 WO disclosed