Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667871 | 0.92 | TP53 (0.44) | MAPTCYP1A2CYP3A4CYP2C19TP53 | |
| SCHEMBL9665356 | 0.90 | MAPT (0.43) | MAPTSMN1; SMN2GAATP53L3MBTL1 | |
| SCHEMBL9667449 | 0.88 | MEN1 (0.46) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL9665440 | 0.86 | TP53 (0.44) | SMN1; SMN2TP53L3MBTL1ATMKMT2A | |
| SCHEMBL10737485 | 0.82 | MEN1 (0.41) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL10738159 | 0.80 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9667378 | 0.79 | CASP3 (0.48) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9666166 | 0.78 | L3MBTL1 (0.43) | MAPTNPC1RAB9ACYP2C19TP53 | |
| SCHEMBL10733852 | 0.78 | PTGS2 (0.42) | MAPTTP53L3MBTL1ATMMEN1 | |
| SCHEMBL9668245 | 0.75 | USP2 (0.42) | MAPTLMNAGAACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |