Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667758 | 0.90 | USP2 (0.43) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL9666290 | 0.89 | USP2 (0.42) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL9667378 | 0.84 | CASP3 (0.48) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL10732971 | 0.81 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EDRD2KMT2A | |
| SCHEMBL7236050 | 0.80 | ALDH1A1 (0.45) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL9667449 | 0.78 | MEN1 (0.46) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL7242408 | 0.77 | ALDH1A1 (0.43) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL10742903 | 0.76 | POLB (0.41) | USP2ALDH1A1GAAKDM4ETSHR | |
| SCHEMBL9665356 | 0.72 | MAPT (0.43) | GAAATMKMT2AMEN1MAPT | |
| SCHEMBL7236836 | 0.71 | USP2 (0.43) | USP2ALDH1A1GAAKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |