SCHEMBL9667397

SCHEMBL9667397

Clc1ccc(C23OCC(C4CCCC4)(CO2)CO3)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 8/20 0.39
SLC6A4 P31645 7/20 0.39
SLC6A2 P23975 5/20 0.39
CHRNA1 P02708 2/20 0.39
CHRNG P07510 2/20 0.39
CHRNB1 P11230 2/20 0.39
CHRNB2 P17787 2/20 0.39
CHRNB4 P30926 2/20 0.39
CHRNA3 P32297 2/20 0.39
CHRNA4 P43681 2/20 0.39
CHRND Q07001 2/20 0.39
MAOA P21397 2/20 0.34
MAOB P27338 2/20 0.34
KDM1A O60341 1/20 0.34
OPRM1 P35372 1/20 0.34
OPRL1 P41146 1/20 0.34
SLC18A3 Q16572 1/20 0.34
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
KCNH2 Q12809 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9667469 0.98 SLC6A3 (0.38) SLC6A3SLC6A4SLC6A2CHRNA1CHRNG
SCHEMBL9668821 0.81 HSD11B1 (0.39) SLC6A3SLC6A4SLC6A2CHRNA1CHRNG
SCHEMBL9668882 0.81 NPC1 (0.32) MEN1KMT2A
SCHEMBL9669218 0.81 SLC6A4 (0.47) SLC6A3SLC6A4SLC6A2CHRNA1CHRNG
SCHEMBL9451466 0.79
SCHEMBL9796866 0.79 ALDH1A1 (0.36) SLC6A3SLC6A4SLC6A2CHRNA1CHRNG
SCHEMBL9796889 0.78 GAA (0.35) CYP3A4CYP2D6CYP1A2CYP2C19
SCHEMBL9204134 0.78
SCHEMBL9667455 0.78 MAOA (0.41) MAOAMAOBCYP3A4MEN1KMT2A
SCHEMBL9796709 0.76 SLC6A2 (0.31) SLC6A3SLC6A4SLC6A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0152229-B1 A CLASS OF PESTICIDES COMPRISING 1,4-BIS-SUBSTITUTED-2,6,7-TRIOXABICYCLO(2.2.2)OCTANES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1992-04-22 EP claimed
EP-0152229-A2 A class of pesticides comprising 1,4-bis-substituted-2,6,7-trioxabicyclo(2.2.2)octanes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1985-08-21 EP claimed
WO-1985003203-A1 A NEW CLASS OF PESTICIDES COMPRISING 1,4-BIS-SUBSTITUTED-2,6,7-TRIOXABICYCLO AD2.2.2. BD OCTANES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1985-08-01 WO claimed
EP-0235979-B1 PESTICIDAL FORMULATIONS THE WELLCOME FOUNDATION LIMITED (GB) 1989-05-31 EP disclosed
EP-0235979-A1 Pesticidal formulations THE WELLCOME FOUNDATION LIMITED (GB) 1987-09-09 EP disclosed