SCHEMBL966871

SCHEMBL966871

Cc1cc(OC(F)(F)F)ccc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRB P28702 2/20 0.50
RXRA P19793 1/20 0.50
IGF2BP2 Q9Y6M1 1/20 0.49
AKR1C2 P52895 1/20 0.48
AKR1C1 Q04828 1/20 0.48
PIM1 P11309 1/20 0.48
KCNK2 O95069 1/20 0.47
KCNK10 P57789 1/20 0.47
FFAR4 Q5NUL3 2/20 0.45
PPARG P37231 1/20 0.45
PPARD Q03181 1/20 0.45
PPARA Q07869 1/20 0.45
AURKA O14965 1/20 0.44
TPX2 Q9ULW0 1/20 0.44
PTGS1 P23219 4/20 0.44
PTGS2 P35354 4/20 0.44
EPHX2 P34913 2/20 0.43
FAAH O00519 1/20 0.43
HTT P42858 1/20 0.43
DHODH Q02127 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2326026 0.86 IGF2BP2 (0.49) IGF2BP2AKR1C2AKR1C1PIM1KCNK2
SCHEMBL31168096 0.85 ABL1 (0.47) IGF2BP2FFAR4PPARGPPARDPPARA
SCHEMBL965069 0.85 CHEK1 (0.46) IGF2BP2PIM1FFAR4PPARGPPARD
SCHEMBL4666472 0.85 FFAR4 (0.44) IGF2BP2AKR1C2AKR1C1PIM1FFAR4
SCHEMBL5127944 0.84 RXRB (0.49) RXRBRXRAAKR1C2HTTALDH1A1
Hydrochloric Acid SCHEMBL7999913 0.83 CHEK1 (0.45) IGF2BP2PIM1FFAR4PPARGPPARD
SCHEMBL20188661 0.82 POLB (0.50) FFAR4PPARGPPARDPPARAEPHX2
SCHEMBL8570264 0.82 PPARG (0.50) IGF2BP2PPARGPPARDPPARAEPHX2
SCHEMBL12586119 0.81 ALDH1A1 (0.55) IGF2BP2AKR1C2AKR1C1PIM1KCNK2
SCHEMBL3301071 0.81 ALDH1A1 (0.51) RXRBRXRAHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720053-A1 LACTAM PESTICIDAL COMPOUNDS BASF SE (DE) 2026-04-08 EP disclosed
US-12441703-B2 Carboxamides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-10-14 US disclosed
WO-2024240859-A1 LACTAM PESTICIDAL COMPOUNDS BASF SE (DE) 2024-11-28 WO disclosed
EP-4467535-A1 LACTAM PESTICIDAL COMPOUNDS BASF SE (DE) 2024-11-27 EP disclosed
US-20230062053-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED 2023-03-02 US disclosed
US-20230062053-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED 2023-03-02 US disclosed
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2021-06-24 US disclosed
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2021-06-24 US disclosed
US-20210017174-A1 IDENTIFICATION AND USE OF ERK5 INHIBITOR BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2021-01-21 US disclosed
EP-3762379-A1 IDENTIFICATION AND USE OF ERK5 INHIBITORS Bayer Aktiengesellschaft (DE) 2021-01-13 EP disclosed
US-20070082907-A1 Peroxisome proliferator activated receptor modulators ELI LILLY AND COMPANY (IN) 2007-04-12 US disclosed
EP-1768973-A1 SUBSTITUTED QUINOLONES AiCuris GmbH & Co. KG (DE) 2007-04-04 EP disclosed
WO-2007003308-A1 SUBSTITUTED QUINOLONES II AICURIS GMBH & CO. KG (DE) 2007-01-11 WO disclosed
EP-1622610-B1 1-(2H-PYRAZOL-3-YL)-3-{4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS AVENTIS PHARMA INC (US) 2006-12-20 EP disclosed
EP-1697304-A1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2006-09-06 EP disclosed
US-20060063796-A1 Pyrazoles as inhibitors of tumor necrosis factor AVENTIS PHARMACEUTICALS INC. (US) 2006-03-23 US disclosed
EP-1622610-A1 1-(2H-PYRAZOL-3-YL)-3- 4-[1-(BENZOYL)-PIPERIDIN-4-YLMETHYL]-PHENYL -UREA DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS Aventis Pharmaceuticals Inc. (US) 2006-02-08 EP disclosed
WO-2006008046-A1 SUBSTITUTED QUINOLONES AICURIS GMBH & CO. KG (DE) 2006-01-26 WO disclosed
WO-2005054176-A1 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2005-06-16 WO disclosed
WO-2004100946-A1 1- (2H-PYRAZOL -3-YL) -3YL) {4-`1- (BENZOYL) -PIPERIDIN-4-YLMETHYL!-PHENYL}-UREA DERIVATIVES AND RELATED COMPOUNDS AS INHBITORS OF P38 KINASE AND/OR TNF INHIBITORS FOR THE TREATMENT OF IMFLAMMATIONS AVENTIS PHARMACEUTICALS INC. (US) 2004-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210017174-A1 IDENTIFICATION AND USE OF ERK5 INHIBITOR MAPK15, MAPKAPK5, MAP3K5 RXRB 3584/4885RXRA 3772/4885IGF2BP2 3360/4885
US-12441703-B2 Carboxamides as modulators of sodium channels TRPV1, SCN2A, SCN10A RXRB 2814/4885RXRA 2370/4885IGF2BP2 4636/4885
US-20060063796-A1 Pyrazoles as inhibitors of tumor necrosis factor TNF, LITAF, MAPK1 RXRB 2188/4885RXRA 2741/4885IGF2BP2 3903/4885
US-20070082907-A1 Peroxisome proliferator activated receptor modulators PPARG, PPARA, PPARD RXRB 32/4885RXRA 34/4885IGF2BP2 2809/4885
US-20230062053-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS TRPV1, SCN2A, SCN10A RXRB 2814/4885RXRA 2370/4885IGF2BP2 4636/4885
US-20210188839-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B RXRB 2030/4885RXRA 2238/4885IGF2BP2 4763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.