Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.46 |
| ▸ | CTSB | P07858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | CTSH | P09668 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CASP6 | P55212 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27227450 | 0.81 | GPR35 (0.42) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL31189991 | 0.81 | L3MBTL1 (0.44) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL1589012 | 0.81 | TDP1 (0.44) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL952538 | 0.81 | CTSB (0.47) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| Bromide SCHEMBL3917241 | 0.79 | L3MBTL1 (0.43) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL801581 | 0.78 | CTSB (0.62) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL30271385 | 0.78 | MAPT (0.53) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL29154637 | 0.78 | GPR35 (0.43) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL8710611 | 0.78 | MAPT (0.53) | GPR35CTSBSMN1; SMN2TSHRTP53 | |
| SCHEMBL2128415 | 0.77 | GPR35 (0.38) | GPR35CTSBSMN1; SMN2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218177-B | Preparation method of 2, 6-dichloro-3-nitropyridine | 新发药业有限公司 | 2020-11-20 | — | — | CN | claimed |
| CN-110218177-A | A kind of preparation method of 2,6- dichloro-3-nitropyridine | 新发药业有限公司 | 2019-09-10 | — | — | CN | claimed |
| CN-110218177-B | Preparation method of 2, 6-dichloro-3-nitropyridine | 新发药业有限公司 | 2020-11-20 | — | — | CN | disclosed |
| CN-110218177-B | Preparation method of 2, 6-dichloro-3-nitropyridine | 新发药业有限公司 | 2020-11-20 | — | — | CN | disclosed |
| CN-110218177-A | A kind of preparation method of 2,6- dichloro-3-nitropyridine | 新发药业有限公司 | 2019-09-10 | — | — | CN | disclosed |
| CN-110218177-A | A kind of preparation method of 2,6- dichloro-3-nitropyridine | 新发药业有限公司 | 2019-09-10 | — | — | CN | disclosed |
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |