Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645173 | 0.80 | ALOX5 (0.54) | ALOX5CYP3A4NAMPTPKMALDH1A1 | |
| SCHEMBL9603339 | 0.76 | ALOX5 (0.74) | ALOX5NAMPTPKMMAPK10ALDH1A1 | |
| SCHEMBL9597381 | 0.74 | ALOX5 (0.80) | ALOX5PKMALDH1A1KDM4EBRD4 | |
| SCHEMBL2413941 | 0.72 | NAMPT (0.51) | CYP3A4NAMPTP2RX7HSD17B13KDM4E | |
| SCHEMBL5716528 | 0.72 | CYP3A4 (0.44) | CYP3A4NAMPTPKMALDH1A1BRD4 | |
| SCHEMBL9596075 | 0.70 | ALOX5 (1.00) | ALOX5ALDH1A1KDM4E | |
| SCHEMBL25202486 | 0.69 | HSD17B13 (0.42) | NAMPTHSD17B13RAB9A | |
| SCHEMBL30426687 | 0.69 | HSD17B13 (0.42) | NAMPTHSD17B13RAB9A | |
| SCHEMBL2413942 | 0.69 | HDAC1 (0.52) | CYP3A4NAMPTKDM4EPOLB | |
| SCHEMBL27218620 | 0.68 | KCNK13 (0.43) | CYP3A4NAMPTP2RX7ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284174-B1 | THERAPEUTIC PREPARATIONS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-29 | — | — | EP | disclosed |