Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.44 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211853 | 0.87 | ALDH1A1 (0.58) | ALDH1A1ALDH5A1ABATVCAM1TDP1 | |
| SCHEMBL9670506 | 0.81 | TDP1 (0.62) | ALDH1A1ALDH5A1ABATVCAM1TDP1 | |
| SCHEMBL9763412 | 0.78 | ALDH1A1 (0.55) | ALDH1A1TDP1TSHRMAPTERN1 | |
| SCHEMBL9735773 | 0.78 | ALDH1A1 (0.69) | ALDH1A1TDP1TSHRMAPTHPGD | |
| SCHEMBL8668528 | 0.77 | TSHR (0.66) | ALDH1A1TDP1TSHRMAPTHPGD | |
| SCHEMBL11284187 | 0.77 | ERN1 (0.56) | ALDH1A1TDP1TSHRMAPTERN1 | |
| SCHEMBL9734521 | 0.76 | ALDH1A1 (0.67) | ALDH1A1TDP1TSHRMAPTHPGD | |
| SCHEMBL5784407 | 0.76 | ALDH1A1 (0.61) | ALDH1A1TDP1TSHRMAPTMEN1 | |
| SCHEMBL2934866 | 0.76 | ALDH1A1 (0.61) | ALDH1A1TDP1TSHRMAPTMEN1 | |
| SCHEMBL7835608 | 0.76 | ALDH1A1 (0.61) | ALDH1A1TDP1TSHRMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155113-A | Administering 5-fluorouracil and derivatives with pyridine and pyridone derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| EP-0180188-B1 | A COMPOSITION FOR INCREASING THE ANTI-CANCER ACTIVITY OF AN ANTI-CANCER COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |
| EP-0180188-A2 | A composition for increasing the anti-cancer activity of an anti-cancer compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-05-07 | — | — | EP | disclosed |