Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10426027 | 1.00 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11703699 | 1.00 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL28728354 | 0.98 | KDM4E (0.52) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9670784 | 0.98 | SIGMAR1 (0.53) | SIGMAR1L3MBTL1MAOA | |
| Iodide SCHEMBL9672333 | 0.96 | SIGMAR1 (0.52) | SIGMAR1L3MBTL1MAOA | |
| Bromide SCHEMBL29198641 | 0.96 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL11134605 | 0.96 | MAOA (0.52) | SIGMAR1KDM4EALDH1A1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11805981 | 0.94 | MEN1 (0.54) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| Iodide SCHEMBL9670517 | 0.94 | CHRM2 (0.51) | SIGMAR1KDM4EALDH1A1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11810419 | 0.93 | MEN1 (0.53) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4820308-A | AMINE-SUBSTITUTED POLYSILOXANES, QUATERNIZED CELLULOSE ETHERS, CYCLOPOLYMERS | L'OREAL (FR) | 1989-04-11 | — | — | US | disclosed |
| US-4710314-A | BLEND OF SOAP, CATION OLYMERS AND SURFACTANTS | L'OREAL (FR) | 1987-12-01 | — | — | US | disclosed |