Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.46 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.46 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9398069 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HPGDEPHX1KMT2AMEN1 | |
| SCHEMBL9670565 | 0.80 | HSP90AA1 (0.50) | ALDH1A1HPGDEPHX1KMT2AMEN1 | |
| SCHEMBL9747776 | 0.77 | NCEH1 (0.41) | KCNJ11ABCC9ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL776594 | 0.77 | KCNJ11 (0.63) | KCNJ11ABCC9ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL11610785 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HPGDEPHX1KMT2AMEN1 | |
| SCHEMBL10447849 | 0.75 | ALDH1A1 (0.71) | KCNJ11ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL18415509 | 0.74 | TSHR (0.48) | KCNJ11ABCC9ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL11116162 | 0.74 | CYP1A2 (0.46) | KCNJ11ABCC9ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL9665541 | 0.73 | KMT2A (0.50) | KCNJ11ABCC9ABCC8KCNJ8ALDH1A1 | |
| SCHEMBL775301 | 0.73 | SMN1; SMN2 (0.56) | KCNJ11ABCC9ABCC8KCNJ8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283959-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-02 | — | — | EP | disclosed |
| US-4912108-A | Containing hydroxy substitution | A/S FERROSAN (DK) | 1990-03-27 | — | — | US | disclosed |
| US-4889855-A | ADMINISTERING GLUTAMATE ANTAGONIST TO INHIBIT HYPERACTIVITY OF EXCITATORY NEUROTRANSMITTERS | A/S FERROSAN (DK) | 1989-12-26 | — | — | US | disclosed |
| EP-0283959-A1 | Heterocyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-09-28 | — | — | EP | disclosed |