Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | TDO2 | P48775 | 2/20 | 0.50 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028779 | 0.83 | ALDH1A1 (0.73) | LMNAALDH1A1HTTKDM4EIDO1 | |
| SCHEMBL5028796 | 0.83 | LMNA (0.57) | LMNAALDH1A1HTTKDM4EIDO1 | |
| SCHEMBL1129120 | 0.82 | ALDH1A1 (0.54) | LMNAALDH1A1HTTIDO1TDO2 | |
| SCHEMBL12565558 | 0.81 | GSR (0.51) | LMNAALDH1A1HTTKDM4ETDP1 | |
| SCHEMBL9670555 | 0.80 | NPC1 (0.58) | LMNAALDH1A1HTTKDM4EKMT2A | |
| SCHEMBL1129588 | 0.80 | L3MBTL1 (0.68) | LMNAALDH1A1KMT2AL3MBTL1MAPT | |
| SCHEMBL1129431 | 0.80 | ALDH1A1 (0.49) | LMNAALDH1A1HTTIDO1TDO2 | |
| SCHEMBL5028773 | 0.80 | ALDH1A1 (0.71) | LMNAALDH1A1HTTKDM4EIDO1 | |
| SCHEMBL1129535 | 0.80 | ALDH1A1 (0.49) | LMNAALDH1A1HTTKDM4ETDP1 | |
| SCHEMBL6279693 | 0.79 | KDM4E (0.62) | LMNAALDH1A1HTTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276825-B1 | 4 (3H)-QUINAZOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-09-09 | — | — | EP | disclosed |
| US-5008266-A | Antiulcer agent | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |
| US-4861780-A | 4(3H)-quinazolinone derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| EP-0276825-A1 | 4 (3H)-Quinazolinone derivatives, processes for their preparation and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |