Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129529 | 0.86 | MAPT (0.52) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL1129745 | 0.86 | L3MBTL1 (0.55) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL1129420 | 0.86 | L3MBTL1 (0.55) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL1129305 | 0.85 | HPGD (0.50) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL1129814 | 0.83 | NTSR1 (0.49) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL30193213 | 0.82 | MEN1 (0.56) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL5025872 | 0.82 | MEN1 (0.56) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL1129587 | 0.82 | PIK3CG (0.51) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL5028779 | 0.81 | ALDH1A1 (0.73) | L3MBTL1TP53LMNAMEN1KMT2A | |
| SCHEMBL14978829 | 0.80 | L3MBTL1 (0.49) | L3MBTL1TP53LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283151-B1 | DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET | F2G LTD (GB) | 2017-03-08 | — | — | EP | disclosed |
| US-9034887-B2 | Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof | F2G LIMITED (GB) | 2015-05-19 | — | — | US | disclosed |
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110160231-A1 | DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF | F2G LIMITED (GB) | 2011-06-30 | — | — | US | disclosed |
| EP-2283151-A2 | DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009133379-A2 | ANTIFUNGAL TARGET | F2G LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | AIFM1, BAX, HSPE1 | L3MBTL1 421/4885TP53 101/4885LMNA 1467/4885 |
| US-20110160231-A1 | DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF | DHODH, DHRS9, DLD | L3MBTL1 4206/4885TP53 1452/4885LMNA 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.