Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1A1 | P14550 | 6/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9674196 | 0.91 | AKR1A1 (0.40) | AKR1A1AKR1B1GSK3BCDK5CDK5R1 | |
| SCHEMBL9673138 | 0.86 | AKR1B1 (0.50) | AKR1A1AKR1B1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9671751 | 0.82 | AKR1B1 (0.44) | AKR1A1AKR1B1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9671932 | 0.76 | PDK2 (0.36) | AKR1A1AKR1B1GSK3BCDK5CDK5R1 | |
| SCHEMBL9672313 | 0.74 | AKR1B1 (0.38) | AKR1A1AKR1B1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9672482 | 0.74 | AKR1B1 (0.41) | AKR1A1AKR1B1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9672344 | 0.73 | AKR1A1 (0.74) | AKR1A1AKR1B1 | |
| SCHEMBL9673448 | 0.67 | ITGA4 (0.44) | AKR1A1AKR1B1GSK3BMAPT | |
| SCHEMBL9672056 | 0.66 | AKR1A1 (0.76) | AKR1A1AKR1B1 | |
| SCHEMBL9672965 | 0.65 | AKR1B1 (0.56) | AKR1A1AKR1B1GSK3BCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137333-B1 | SPIRO-TRICYCLICAROMATIC SUCCINIMIDE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | ALCON LABORATORIES, INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4717725-A | SPIROCYCLIC AROMATIC IMIDES | ALCON LABORATORIES, INC. (US) | 1988-01-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |