Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 16/20 | 0.62 |
| ▸ | RAB9A | P51151 | 13/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.62 |
| ▸ | MITF | O75030 | 8/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.52 |
| ▸ | LMNA | P02545 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.52 |
| ▸ | XBP1 | P17861 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737468 | 1.00 | HTT (0.62) | HTTRAB9ANPSR1MITFPKM | |
| SCHEMBL9736840 | 0.86 | HTT (0.47) | HTTRAB9ANPSR1MITFPKM | |
| SCHEMBL9736838 | 0.86 | HTT (0.47) | HTTRAB9ANPSR1MITFPKM | |
| SCHEMBL9125192 | 0.86 | RAB9A (0.54) | HTTRAB9ANPSR1MITFPKM | |
| SCHEMBL9125199 | 0.86 | RAB9A (0.54) | HTTRAB9ANPSR1MITFPKM | |
| SCHEMBL9735984 | 0.83 | ALDH1A1 (0.53) | HTTRAB9ANPSR1MITFALDH1A1 | |
| SCHEMBL9674148 | 0.83 | ALDH1A1 (0.53) | HTTRAB9ANPSR1MITFALDH1A1 | |
| SCHEMBL9736113 | 0.72 | SLC6A2 (0.49) | HTTRAB9ANPSR1MITFALDH1A1 | |
| SCHEMBL9674128 | 0.72 | SLC6A2 (0.49) | HTTRAB9ANPSR1MITFALDH1A1 | |
| SCHEMBL18454453 | 0.71 | HTT (0.48) | HTTRAB9ANPSR1MITFPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517877-A1 | NOVEL 3(2H)-PYRIDAZINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1992-12-16 | — | — | EP | disclosed |
| WO-1992012137-A1 | NOVEL 3(2H)-PYRIDAZINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1992-07-23 | — | — | WO | disclosed |