Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.79 |
| ▸ | PTAFR | P25105 | 19/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9674052 | 0.91 | PTAFR (0.84) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9672548 | 0.91 | PTAFR (0.85) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL30665015 | 0.89 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL42920 | 0.89 | OPRK1 (1.00) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9667837 | 0.87 | OPRK1 (0.81) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL8928483 | 0.87 | OPRK1 (0.84) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| Etizolam SCHEMBL10869413 | 0.86 | OPRK1 (0.90) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9654335 | 0.86 | OPRK1 (0.76) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9672536 | 0.85 | PTAFR (0.82) | OPRK1PDE4DPTAFRCYP3A4ALOX15 | |
| SCHEMBL9672719 | 0.85 | PTAFR (0.84) | OPRK1PDE4DPTAFRCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268242-B1 | PAF-ANTAGONISTIC THIENOTRIAZOLODIAZEPINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4820703-A | TREATMENT OF INFLAMMATORY, RESPIRATORY AND CARDIOVASCULAR DISEASES | YOSHITOMI PHARMACEUTICAL INDUSTRIES LTD. (JP) | 1989-04-11 | — | — | US | disclosed |
| EP-0268242-A1 | PAF-antagonistic thienotriazolodiazepine compounds and pharmaceutical uses thereof | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-05-25 | — | — | EP | disclosed |