Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25C | P30307 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678220 | 0.91 | CDC25C (0.49) | CDC25CMEN1KMT2ATHRBAPEX1 | |
| SCHEMBL9678236 | 0.79 | CDC25C (0.51) | CDC25CMEN1KMT2ATHRBAPEX1 | |
| SCHEMBL9676534 | 0.77 | GRK6 (0.67) | MEN1KMT2ATDP1SIGMAR1RAB9A | |
| SCHEMBL31312575 | 0.76 | ALDH1A1 (0.60) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9641204 | 0.76 | RAB9A (0.56) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8139921 | 0.76 | RAB9A (0.56) | MEN1KMT2ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3143117 | 0.76 | KCNH2 (0.64) | CDC25CMEN1KMT2ATHRBAPEX1 | |
| SCHEMBL9675487 | 0.75 | CDC25C (0.55) | CDC25CMEN1KMT2ATHRBAPEX1 | |
| SCHEMBL9628028 | 0.74 | KCNH2 (0.74) | CDC25CMEN1KMT2ATHRBAPEX1 | |
| SCHEMBL6635764 | 0.74 | GRK6 (0.48) | MEN1KMT2AKCNH2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158964-A | Benzoxazole sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055473-A | QUINOLINYL SULFONAMIDE ANTI-ARRHYTHMIC AGENTS AND USE THEREAS | PFIZER INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4956382-A | TERTIARY AMINE HETEROCYCLIC SULFONAMIDES | PFIZER INC. (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0281254-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-01-17 | — | — | EP | disclosed |
| EP-0281254-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-09-07 | — | — | EP | disclosed |