Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25C | P30307 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5936119 | 0.83 | MAPT (0.46) | MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL9737428 | 0.81 | KCNH2 (0.59) | MEN1KMT2AKCNH2ACHE | |
| SCHEMBL3143117 | 0.78 | KCNH2 (0.64) | CDC25CMEN1THRBAPEX1RECQL | |
| SCHEMBL9678220 | 0.78 | CDC25C (0.49) | CDC25CMEN1THRBAPEX1RECQL | |
| SCHEMBL6231422 | 0.78 | TTR (0.43) | KMT2ACRHBPCRHR2ALDH1A1ACHE | |
| SCHEMBL6231424 | 0.78 | TTR (0.43) | KMT2ACRHBPCRHR2ALDH1A1ACHE | |
| SCHEMBL9628028 | 0.77 | KCNH2 (0.74) | CDC25CMEN1THRBAPEX1RECQL | |
| SCHEMBL14127817 | 0.76 | KDM4E (0.55) | KMT2ATDP1ALDH1A1NPBWR1 | |
| SCHEMBL9678053 | 0.76 | LMNA (0.44) | MEN1KMT2AKCNH2SIGMAR1ALDH1A1 | |
| SCHEMBL9675455 | 0.75 | CDC25C (0.52) | CDC25CMEN1THRBAPEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158964-A | Benzoxazole sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5055473-A | QUINOLINYL SULFONAMIDE ANTI-ARRHYTHMIC AGENTS AND USE THEREAS | PFIZER INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4956382-A | TERTIARY AMINE HETEROCYCLIC SULFONAMIDES | PFIZER INC. (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0281254-B1 | ANTIARRYTHMIC AGENTS | Pfizer Limited (GB) | 1990-01-17 | — | — | EP | disclosed |
| EP-0281254-A1 | Antiarrythmic agents | Pfizer Limited (GB) | 1988-09-07 | — | — | EP | disclosed |