Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.59 |
| ▸ | LSS | P48449 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9737655 | 0.89 | KCNH2 (0.59) | KCNH2LSSBCHEACHELMNA | |
| SCHEMBL9675487 | 0.81 | CDC25C (0.55) | KCNH2ACHEMEN1KMT2A | |
| SCHEMBL9736462 | 0.81 | KCNH2 (0.58) | KCNH2LSSBCHEACHELMNA | |
| SCHEMBL5936119 | 0.79 | MAPT (0.46) | LMNAMAPTMEN1KMT2A | |
| SCHEMBL9737271 | 0.78 | MAPT (0.45) | KCNH2LMNAPOLBMAPTKMT2A | |
| SCHEMBL9738867 | 0.76 | ALDH1A1 (0.38) | KCNH2CHRNB2CHRNA4LMNAPOLB | |
| SCHEMBL8810787 | 0.75 | KCNH2 (0.81) | KCNH2ACHELMNAMEN1KMT2A | |
| SCHEMBL6231424 | 0.74 | TTR (0.43) | ACHELMNAMAPTKMT2A | |
| SCHEMBL6231422 | 0.74 | TTR (0.43) | ACHELMNAMAPTKMT2A | |
| SCHEMBL9736383 | 0.74 | KCNH2 (0.50) | KCNH2ACHELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084463-A | Cardiovascular disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-28 | — | — | US | disclosed |