Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 7/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2429422 | 0.84 | PARP14 (0.51) | ALDH1A1MAPK1HSD17B10PARP14KIF11 | |
| SCHEMBL4786156 | 0.83 | SLC22A6 (0.55) | ALDH1A1HSD17B10PTGS1PARP14KIF11 | |
| SCHEMBL27500727 | 0.83 | PARP14 (0.49) | ALDH1A1HSD17B10PARP14KIF11TP53 | |
| SCHEMBL15560416 | 0.81 | KIF11 (0.47) | ALDH1A1HSD17B10GAAPARP14KIF11 | |
| SCHEMBL11584101 | 0.80 | EGFR (0.46) | ALDH1A1MAPK1HSD17B10PARP14KIF11 | |
| SCHEMBL3924071 | 0.79 | PARP14 (0.50) | ALDH1A1PARP14KIF11TP53MAPT | |
| SCHEMBL299311 | 0.79 | PARP14 (0.47) | ALDH1A1MAPK1HSD17B10PARP14KIF11 | |
| SCHEMBL11537835 | 0.78 | KIF11 (0.45) | ALDH1A1MAPK1HSD17B10PARP14KIF11 | |
| SCHEMBL6601301 | 0.78 | PARP14 (0.51) | ALDH1A1GAAPARP14KIF11TP53 | |
| SCHEMBL29001995 | 0.78 | KIF11 (0.44) | PARP14KIF11TP53MAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416024-A4 | SUBSTITUTED 6H-PYRIDO (4,3-B) CARBAZOLES | — | 1992-04-15 | — | — | EP | disclosed |
| EP-0416024-A1 | SUBSTITUTED 6H-PYRIDO (4,3-b) CARBAZOLES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989011480-A1 | SUBSTITUTED 6H-PYRIDO (4,3-b) CARBAZOLES | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1989-11-30 | — | — | WO | disclosed |
| US-4851417-A | 9-substituted 6H-pyrido[4,3-b]carbazoles | RENSSELAER POLYTECHNIC INSTITUTE (US) | 1989-07-25 | — | — | US | disclosed |