Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 6/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27500727 | 0.88 | PARP14 (0.49) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL27875227 | 0.86 | KMT2A (0.55) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL4786156 | 0.85 | SLC22A6 (0.55) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL31400290 | 0.83 | PBRM1 (0.50) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL2429422 | 0.83 | PARP14 (0.51) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL29001995 | 0.83 | KIF11 (0.44) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL299425 | 0.81 | JAK2 (0.43) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL299311 | 0.81 | PARP14 (0.47) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL3924071 | 0.81 | PARP14 (0.50) | KIF11MAPTHTTJAK2TP53 | |
| SCHEMBL9676604 | 0.81 | ALDH1A1 (0.59) | KIF11MAPTHTTJAK2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852572-A1 | CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | Eli Lilly and Company (US) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013176698-A1 | CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | ELI LILLY AND COMPANY (US) | 2013-11-28 | — | — | WO | disclosed |