Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833283 | 0.88 | GBA1 (0.46) | ROCK2ARHGDIAROCK1MAPTGBA1 | |
| SCHEMBL5833930 | 0.83 | ROCK2 (0.42) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL6180409 | 0.82 | KDM4E (0.44) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL5833647 | 0.82 | ROCK2 (0.45) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL4966861 | 0.78 | MAPT (0.50) | SIGMAR1ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL6545137 | 0.78 | SIGMAR1 (0.44) | SIGMAR1ROCK2ARHGDIAROCK1MAPT | |
| Hydrochloric Acid SCHEMBL6707460 | 0.77 | SIGMAR1 (0.43) | SIGMAR1ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL5833935 | 0.76 | ROCK2 (0.41) | SIGMAR1ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL5833927 | 0.76 | ROCK2 (0.43) | SIGMAR1ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL6180405 | 0.76 | MTNR1A (0.47) | ROCK2ARHGDIAROCK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510129-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1992-10-28 | — | — | EP | disclosed |