Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678342 | 0.82 | SIGMAR1 (0.45) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL5833930 | 0.80 | ROCK2 (0.42) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL5833647 | 0.79 | ROCK2 (0.45) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL5833283 | 0.79 | GBA1 (0.46) | ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL6180405 | 0.76 | MTNR1A (0.47) | BRD4ROCK2ARHGDIAROCK1MAPT | |
| SCHEMBL6713113 | 0.75 | PKM (0.40) | BRD4ROCK2ARHGDIAROCK1HSD17B10 | |
| SCHEMBL6708297 | 0.75 | DRD2 (0.47) | — | |
| Hydrochloric Acid SCHEMBL6708207 | 0.75 | MTNR1A (0.46) | BRD4ROCK2ARHGDIAROCK1MAPT | |
| Hydrochloric Acid SCHEMBL6709532 | 0.74 | DRD2 (0.46) | — | |
| SCHEMBL6545449 | 0.74 | MTNR1A (0.46) | BRD4ROCK2ARHGDIAROCK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317430-B1 | (2-AZABICYCLO [2.2.1]HEPT-7-YL)METHANOL DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS | MERCK PATENT GMBH (DE) | 2005-05-18 | — | — | EP | disclosed |