SCHEMBL968053

SCHEMBL968053

CCCCC[C@@H](/C=C/I)O[Si](C)(C)C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.32
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
CA1 P00915 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4975284 1.00 CA2 (0.32) CA2MEN1KMT2ACA1
SCHEMBL11491429 1.00 CA2 (0.32) CA2MEN1KMT2ACA1
SCHEMBL968055 1.00 CA2 (0.32) CA2MEN1KMT2ACA1
SCHEMBL4975291 1.00 CA2 (0.32) CA2MEN1KMT2ACA1
SCHEMBL8838682 1.00 CA2 (0.32) CA2MEN1KMT2ACA1
SCHEMBL9547867 1.00 CA2 (0.32) CA2MEN1KMT2ACA1
SCHEMBL4975685 0.98 MEN1 (0.32) CA2MEN1KMT2A
SCHEMBL11405856 0.98 MEN1 (0.32) CA2MEN1KMT2A
SCHEMBL4975682 0.98 MEN1 (0.32) CA2MEN1KMT2A
SCHEMBL11405854 0.98 MEN1 (0.32) CA2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0624574-B1 Novel prostaglandin analogue MIZUSHIMA YUTAKA (JP) 1999-04-21 EP claimed
EP-0624574-A2 Novel prostaglandin analogue MIZUSHIMA, Yutaka (JP) 1994-11-17 EP claimed
EP-2864308-B1 (3aR,6aS)-2-Hydroxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde intermediates for the preparation of prostaglandins or prostaglandin analogues UNIV BRISTOL (GB) 2016-10-19 EP disclosed
EP-2864308-B1 (3aR,6aS)-2-Hydroxy-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-5-carbaldehyde intermediates for the preparation of prostaglandins or prostaglandin analogues UNIV BRISTOL (GB) 2016-10-19 EP disclosed
US-20160237056-A1 NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES USING METATHESIS PATHEON API SERVICES INC. 2016-08-18 US disclosed
US-20160237056-A1 NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES USING METATHESIS PATHEON API SERVICES INC. 2016-08-18 US disclosed
US-9242954-B2 Lactol and acetal intermediates for making prostaglandins UNIVERSITY OF BRISTOL (GB) 2016-01-26 US disclosed
US-9242954-B2 Lactol and acetal intermediates for making prostaglandins UNIVERSITY OF BRISTOL (GB) 2016-01-26 US disclosed
US-9242954-B2 Lactol and acetal intermediates for making prostaglandins UNIVERSITY OF BRISTOL (GB) 2016-01-26 US disclosed
US-20150158837-A1 Compound And Method TOPOKINE THERAPEUTICS, INC. 2015-06-11 US disclosed
US-20150158837-A1 Compound And Method TOPOKINE THERAPEUTICS, INC. 2015-06-11 US disclosed
EP-0312055-A2 6-Fluoroprostaglandins ASAHI GLASS COMPANY LTD. (JP) 1989-04-19 EP disclosed
EP-0102230-B1 NOVEL 6-NITROPROSTAGLANDIN DERIVATIVES, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF TEIJIN LIMITED (JP) 1987-04-29 EP disclosed
US-4649156-A ANTICOAGULANTS, HYPOTENSIVE, VASODILATORS, ANTITUMOR TEIJIN LIMITED (JP) 1987-03-10 US disclosed
EP-0178139-A2 Process for producing 2,3-disubstituted -4-substituted cyclopentanones, enantiomorphs, or mixtures thereof TEIJIN LIMITED (JP) 1986-04-16 EP disclosed
EP-0173754-A1 7-THIAPROSTAGLANDIN E 1?'S AND PROCESS FOR THEIR PREPARATION TEIJIN LIMITED (JP) 1986-03-12 EP disclosed
EP-0051284-B1 NOVEL THIAPROSTAGLANDIN E1 DERIVATIVES, PROCESS FOR PRODUCTION THEREOF, AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS TEIJIN LIMITED (JP) 1985-01-09 EP disclosed
US-4466980-A Thiaprostaglandin E1 derivatives, process for production thereof, and pharmaceutical use thereof TEIJIN LIMITED (JP) 1984-08-21 US disclosed
EP-0102230-A2 Novel 6-nitroprostaglandin derivatives, process for production thereof, and use thereof TEIJIN LIMITED (JP) 1984-03-07 EP disclosed
EP-0051284-A1 Novel thiaprostaglandin E1 derivatives, process for production thereof, and pharmaceuticals containing these compounds TEIJIN LIMITED (JP) 1982-05-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160237056-A1 NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES USING METATHESIS PTGES, PTGIS, PTGES2 CA2 1336/4885MEN1 692/4885KMT2A 4105/4885
US-20150158837-A1 Compound And Method CYP4A11, NR1H2, NR1H3 CA2 3363/4885MEN1 2871/4885KMT2A 3218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.