SCHEMBL9680953

SCHEMBL9680953

O=C(O)Oc1cc(-c2ccccc2)c(=O)n2c1-c1sccc1C2

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 1/20 0.35
ALDH1A1 P00352 3/20 0.34
TSHR P16473 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
BCAT2 O15382 1/20 0.33
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
GABRA3 P34903 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
BACE1 P56817 1/20 0.30
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
RECQL P46063 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10367071 0.90 ALDH1A1 (0.34) ALDH1A1TSHRL3MBTL1BCAT2GABRA1
SCHEMBL10369947 0.83 ALDH1A1 (0.32) AGTR2ALDH1A1TSHRL3MBTL1BCAT2
SCHEMBL9682914 0.83 ALDH1A1 (0.40) ALDH1A1TSHRL3MBTL1GABRA1GABRG2
SCHEMBL10367549 0.82 KDM4E (0.35) MAPTKMT2A
SCHEMBL9343257 0.82 AGTR2 (0.37) AGTR2ALDH1A1TSHRL3MBTL1BCAT2
SCHEMBL10368325 0.81 ALDH1A1 (0.33) ALDH1A1TSHRL3MBTL1MEN1MAPT
SCHEMBL10369721 0.80 KCNK3 (0.35) ALDH1A1L3MBTL1GABRA1GABRG2GABRB3
SCHEMBL10367418 0.78 GABRA1 (0.40) ALDH1A1TSHRL3MBTL1GABRA1GABRG2
SCHEMBL10368537 0.78 ALDH1A1 (0.38) AGTR2ALDH1A1TSHRL3MBTL1BCAT2
SCHEMBL10702701 0.78 GABRA1 (0.37) AGTR2ALDH1A1TSHRL3MBTL1GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0472166-A1 Tricyclic pyridone derivatives F. HOFFMANN-LA ROCHE AG (CH) 1992-02-26 EP disclosed