Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991217 | 0.81 | GAA (0.39) | ALDH1A1KDM4EHDAC1CA2HDAC6 | |
| SCHEMBL7212212 | 0.80 | PARP1 (0.45) | CYP3A4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL10636542 | 0.78 | KDM4E (0.37) | ALPLGFERMPOCYP3A4BLM | |
| SCHEMBL6204339 | 0.78 | ALDH1A1 (0.49) | ALPLGFERMPOCYP3A4BLM | |
| SCHEMBL5759254 | 0.77 | ALDH1A1 (0.43) | CYP3A4ALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL4321490 | 0.76 | KEAP1 (0.39) | HIF1AALDH1A1KDM4ECA1CA2 | |
| SCHEMBL27707510 | 0.75 | CES2 (0.33) | ALDH1A1 | |
| SCHEMBL27952340 | 0.74 | TRPM8 (0.35) | CYP3A4ALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL3982238 | 0.74 | MEN1 (0.42) | ALPLALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL4147070 | 0.73 | NPC1 (0.57) | HDAC1CA2HDAC6POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |