Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20581374 | 0.81 | THRB (0.44) | LMNATHRBTSHR | |
| SCHEMBL10571822 | 0.81 | THRB (0.44) | LMNATHRBTSHR | |
| SCHEMBL13573723 | 0.79 | LMNA (0.43) | LMNATHRBTSHR | |
| SCHEMBL13573097 | 0.79 | LMNA (0.43) | LMNATHRBTSHR | |
| SCHEMBL288820 | 0.78 | LMNA (0.47) | LMNATHRB | |
| SCHEMBL1285795 | 0.78 | LMNA (0.47) | LMNATHRB | |
| SCHEMBL8924726 | 0.76 | THRB (0.40) | LMNATHRBTSHR | |
| Ammonia Solution, Strong SCHEMBL22117628 | 0.76 | LMNA (0.45) | LMNATHRB | |
| SCHEMBL7883950 | 0.74 | — | — | |
| SCHEMBL18697930 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106861-A | Method of using certain tetralin derivatives to produce analgesic relief | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0381902-A1 | Tetralin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-16 | — | — | EP | disclosed |