Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682084 | 0.87 | MAPT (0.36) | RXFP1NPSR1MAPTPOLBKDM4E | |
| SCHEMBL9846089 | 0.85 | NPSR1 (0.38) | RXFP1NPSR1MAPTPOLBKDM4E | |
| SCHEMBL9681383 | 0.85 | NPC1 (0.34) | RXFP1NPSR1MAPTPOLBKDM4E | |
| SCHEMBL9846212 | 0.81 | SLC2A1 (0.40) | MAPTPOLBKDM4EPDE3BPDE3A | |
| SCHEMBL9846203 | 0.81 | PDE3B (0.38) | MAPTKDM4EPDE3BPDE3AALDH1A1 | |
| SCHEMBL9846298 | 0.81 | PDE3B (0.38) | MAPTKDM4EPDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL9846175 | 0.79 | PDE3B (0.38) | MAPTPOLBKDM4EPDE3BPDE3A | |
| SCHEMBL9846123 | 0.76 | NPSR1 (0.36) | RXFP1NPSR1MAPTPOLBKDM4E | |
| SCHEMBL27337641 | 0.73 | POLB (0.49) | MAPTPOLBKDM4EPDE3BPDE3A | |
| SCHEMBL9680321 | 0.73 | NPSR1 (0.36) | RXFP1NPSR1MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |