Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681356 | 0.87 | DRD2 (0.47) | KMT2ABCL2A1KDM4EALDH1A1USP2 | |
| Hydrochloric Acid SCHEMBL9683227 | 0.86 | DRD2 (0.46) | KMT2ABCL2A1KDM4EALDH1A1HRH4 | |
| SCHEMBL9681923 | 0.78 | MAT2A (0.65) | MAT2AKMT2AKDM4EALDH1A1USP2 | |
| SCHEMBL9681294 | 0.77 | SCN9A (0.44) | HRH4MAPTHTR3AHTR3BHTR3E | |
| SCHEMBL6125292 | 0.76 | KHK (0.56) | MAT2AKDM4EALDH1A1HRH4HTR6 | |
| Hydrochloric Acid SCHEMBL9682443 | 0.76 | SCN9A (0.43) | KDM4EALDH1A1HRH4MAPTHTR3A | |
| Hydrochloric Acid SCHEMBL9682152 | 0.75 | KHK (0.54) | MAT2AKDM4EALDH1A1HRH4HTR3A | |
| SCHEMBL14922275 | 0.75 | POLB (0.71) | BCL2A1POLBKDM4EALDH1A1HRH4 | |
| SCHEMBL9762766 | 0.73 | KHK (0.52) | KMT2AHRH4MAPTHTR3AHTR3B | |
| SCHEMBL10416166 | 0.72 | HTR3E (0.53) | KMT2AKDM4EALDH1A1HRH4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | claimed |
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |